Publications

The Goldman Group > Research > Publications

Selected publications (full list >200, three citation classics; total citations >10,000; overall H-factor of 41. )

A full list of recent publications is available here: https://orcid.org/0000-0001-8032-9700

A self-maintained full list of all publications is here: https://tinyurl.com/jhkpjb3y

Selected publications (1982-2021)

  1. Hsu, S. D., Lee, Y. C., Mikula, K. M., Backlund, S. M., Tascón, I., Goldman, A. & Iwaï, H. Tying up the Loose Ends: A Mathematically Knotted Protein. Front Chem 9, 663241 (2021).
  2. Pavić, A., Ji, Y., Serafini, A., Garza-Garcia, A., McPhillie, M. J., Holmes, A. O. M., de Carvalho, L. P. S., Wang, Y., Bartlam, M., Goldman, A. & Postis, V. L. G. Functional Characterization of the γ-Aminobutyric Acid Transporter from Mycobacterium smegmatis MC2 155 Reveals Sodium-Driven GABA Transport. J. Bacteriol. 203, e00642–20 (2021).
  3. Harborne, S. P. D., Strauss, J., Boakes, J. C., Wright, D. L., Henderson, J. G., Boivineau, J., Jaakola, V.-P. & Goldman, A. IMPROvER: the Integral Membrane Protein Stability Selector. Sci Rep 10, 15165 (2020).
  4. Johansson, N. G., Turku, A., Vidilaseris, K., Dreano, L., Khattab, A., Ayuso Pérez, D., Wilkinson, A., Zhang, Y., Tamminen, M., Grazhdankin, E., Kiriazis, A., Fishwick, C. W. G., Meri, S., Yli-Kauhaluoma, J., Goldman, A., Boije Af Gennäs, G. & Xhaard, H. Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment. ACS Med Chem Lett 11, 605–610 (2020).
  5. Mikula, K. M., Kolodziejczyk, R. & Goldman, A. Structure of the UspA1 protein fragment from Moraxella catarrhalis responsible for C3d binding. J Struct Biol 208, 77–85 (2019).
  6. Alfaro-Chávez, A. L., Liu, J. W., Stevenson, B. J., Goldman, A. & Ollis, D. L. Evolving a lipase for hydrolysis of natural triglycerides along with enhanced tolerance towards a protease and surfactants. Protein Eng Des Sel 32, 129–143 (2019).
  7. Vidilaseris, K., Kiriazis, A., Turku, A., Khattab, A., Johansson, N. G., Leino, T. O., Kiuru, P. S., Boije Af Gennäs, G., Meri, S., Yli-Kauhaluoma, J., Xhaard, H. & Goldman, A. The structure of Thermotoga maritima membrane bound pyrophosphatase in complex with imidodiphosphate and a novel inhibitor suggests an allosteric catalytic mechanism. Sci Adv. 5, eaav7574 (2019).
  8. Tsai, J.-Y., Tang, K.-Z., Li, K.-M., Hsu, B.-L., Chiang, Y.-W., Goldman, A. & Sun, Y.-J. Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol. 431, 1619–1632 (2019).
  9. Harborne, S. P. D., Wotherspoon, D., Michie, J., McComb, A., Kotila, T., Gilmour, S. & Goldman, A. Revolutionising the design and analysis of protein engineering experiments using fractional factorial design. bioRxiv (2018). DOI: 10.1101/298273
  10. Hassan, K. A., Liu, Q., Elbourne, L. D. H., Ahmad, I., Sharples, D., Naidu, V., Chan, C. L., Li, L., Harborne, S. P. D., Pokhrel, A., Postis, V. L. G., Goldman, A., Henderson, P. J. F. & Paulsen, I. T. Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens. Res Microbiol (2018). DOI: 10.1016/j.resmic.2018.01.001
  11. Robinson, J. I., Baxter, E. W., Owen, R. L., Thomsen, M., Tomlinson, D. C., Waterhouse, M. P., Win, S. J., Nettleship, J. E., Tiede, C., Foster, R. J., Owens, R. J., Fishwick, C. W. G., Harris, S. A., Goldman, A., McPherson, M. J. & Morgan, A. W. Adhirons inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action. Proc. Natl. Acad. Sci. U S A 115, E72-E81 (2018).
  12. Li, K.-M., Wilkinson, C., Kellosalo, J., Tsai, J.-Y., Kajander, T., Jeuken, L. J. C., Sun, Y.-J. & Goldman, A. Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism. Nat. Commun. 7, 13596 (2016).
  13. Lee, S. C., Knowles, T. J., Postis, V. L., Jamshad, M., Parslow, R. A., Lin, Y. P., Goldman, A., Sridhar, P., Overduin, M., Muench, S. P. & Dafforn, T. R. A method for detergent-free isolation of membrane proteins in their local lipid environment. Nat Protoc 11, 1149–1162 (2016).
  14. Happonen, L.J., Oksanen, E., Liljeroos, L., Goldman, A., Kajander, T. & Butcher S.J. The structural basis for function of a thermostable viral NTPase. J. Virol. 87, 8388–8398 (2013).
  15. Meri, T., Amdahl, H., Lehtinen, M. J., Hyvärinen, S., McDowell, J. V., Meri, S., Marconi, R., Goldman, A. & Jokiranta, T. S. Microbes Bind Complement Inhibitor Factor H via a Common Site. PLoS Pathog. 9, e1003308 (2013).
  16. Bhattacharjee, A., Oeemig, J. S., Kolodziejczyk, R., Meri, T., Kajander, T., Iwai, H., Jokiranta, T. S. & Goldman, A. Structural basis for complement evasion by the Lyme disease pathogen Borrelia burgdorferi. J. Biol. Chem. 288, 18685–18695 (2013).
  17. Kellosalo, J., Kajander, T., Kogan, K., Pokharel, K. & Goldman, A. The Structure and Catalytic Cycle of a Sodium-Pumping Pyrophosphatase. Science 337, 473-476 (2012).
  18. Kajander, T., Lehtinen, M. J., Hyvärinen, S., Bhattacharjee, A., Leung, E., Isenman, D. E., Meri, S., Goldman, A. & Jokiranta, S. T. Structure of the FH19-20:C3d complex explains both target recognition and aHUS pathogenesis. Proc. Natl. Acad. Sci U.S.A., 108, 2897-2902 (2011).
  19. Leppänen, V.-M., Prota, A. E., Jeltsch, M., Anisimov, A., Kalkkinen, N., Strandin, T., Lankinen, H., Goldman, A., Ballmer-Hofer, K. & Alitalo, K. Structural determinants of growth factor binding and specificity by VEGF-Receptor 2. Proc. Natl. Acad. Sci. U S A 107, 2425–2430 (2010).
  20. Kajander, T., Sachs, J. N., Goldman, A. & Regan, L. Electrostatic Interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering, J. Biol. Chem., 284, 25364-25374 (2009)
  21. Paavilainen, V., Oksanen, E.J, Goldman, A & Lappalainen, P. Structure of the actin-depolymerizing-factor homology domain in complex with actin, J Cell Biol. 182, 51-59 (2008).
  22. Parkash, V., Leppänen, V.-M., Virtanen, H., Jurvansuu, J. M., Bespalov, M. M., Sidorova, Y. A., Runeberg-Roos, P., Saarma, M. & Goldman, A. The Structure of the GDNF2-GFRα12 complex: Insights into RET signalling and Heparin binding, J. Biol. Chem.283:35164-35172 (2008).
  23. Jokiranta, T. S., Jaakola, V.-P., Pärepalo, M., Lehtinen, M. J., Meri, S. & Goldman, A. Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome. EMBO J., 25, 1784-1794(2006).
  24. Merckel, M. C., Huiskonen, J. T., Bamford, D. H., Goldman, A. & Tuma, R. The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture. Mol. Cell, 18, 161-170 (2005).
  25. Leppänen, V.-M., Bespalov, M., Runeberg-Roos, P., Puurand, Ü., Merits, A., Saarma, M. & Goldman, A. The structure of GFRa1 domain 3 reveals new insights into GDNF binding and RET activation. EMBO J.23, 1452-1462 (2004).
  26. Nummelin, H., Merckel, M. C., Leo, J., Lankinen, H. Skurnik, M. & Goldman, A. The structure of Yersinia adhesin YadA collagen-binding domain is a novel left-handed parallel b-roll. EMBO J., 23, 701-711 (2004).
  27. Kajander, T., Merckel, M. C., Thompson, A., Deacon, A., Mazur, P., Kozarich, J. W. & Goldman, A. The structure of Neurospora crassa 3-carboxy-cis,cis-mcuonate lactonizing enzyme – a b-propeller cycloisomerase. Structure, 10, 483-492, (2002).
  28. Heikinheimo, P., Tuominen, V. U., Ahonen, A.-K., Teplyakov, A., Cooperman, B. S., Baykov, A. A., Lahti, R. & Goldman, A. Toward a Quantum-mechanical description of Metal Assisted Phosphoryl Transfer in Pyrophosphatase. Proc. Natl. Acad. Sci. USA, 98, 3121-3126 (2001)
  29. Merckel, M. C., Fabrichniy, I. P., Salminen, A., Kalkkinen, N., Baykov, A. A., Lahti, R. & Goldman, A. Crystal Structure of Streptococcus mutans Pyrophosphatase: a new fold for an old mechanism. Structure,  9, 289-297 (2001).
  30. Leppänen, V.-M., Merckel, M., Wong, K. K., Kozarich, J. W. & Goldman, A.             Pyruvate Formate Lyase is Structurally Homologous to Type I Ribonucleotide Reductase. Structure, 7, 733-744 (1999).
  31. Heikinheimo, P., Lehtonen, J., Baykov, A. A., Lahti, R., Cooperman, B. S. & Goldman, A. The Structural Basis for Pyrophosphatase Catalysis. Structure, 4: 1491-1508 (1996).
  32. Ollis, D.L., Cheah, E., Cygler, M., Dijkstra, D., Frolow, F., Franken, S.M., Harel, M., Remington, S.J., Silman, I., Schrag, J., Sussman, J.L., Verschueren, K.H.G. & Goldman, A. The alpha/beta Hydrolase Fold.  Protein Eng., 5: 197-211 (1992).
  33. Sussman, J.L., Harel, M., Frolow, F., Oefner, C., Goldman, A., Toker, L. & Silman, I. Atomic Structure of Acetylcholinesterase from Torpedo californica: A Prototypic Acetylcholine-Binding Protein. Science, 253: 872-879 (1991).
  34. Sanderson, M.R., Freemont, P.S., Rice, P.A., Hatfull, G.F., Goldman, A., Grindley, N.D.F. & Steitz, T.A. The Crystal Structure of the Catalytic Domain of the Site-Specific Recombination Enzyme gd Resolvase at 2.7 Å. Cell, 63: 1323-1331 (1990).
  35. Engelman, D.M., Goldman, A. & Steitz, T.A. The Identification of Helical Segments in the Polypeptide Chain of Bacteriorhodopsin. Methods Enzymol., 88: 81-88 (1982).